Sleep deprivation resting state fMRI

Title: Sleep deprivation resting state fMRIAuthor: Ye EnmaoDegree-granting units: Southern Medical UniversityKeywords: sleep deprivation;; functional magnetic resonance imaging;; working memory;; resting state;; functional connectivity;; default networkSummary:Sleep can not only promote the body's growth and development, to maintain the body to survive, more importantly, to maintain attention, memory, learning and other cognitive functions of the normalization of good sleep is essential for the health of individuals. Sleep deprivation (sleep deprivation, SD) is due to various causes loss of sleep states, generally refers to sleep in less than 24h 4h, and cause emotional, learning and memory, immune function and a series of Neodymium Magnets changes can be accompanied by an increase in fatigue caused by a series of physiological, psychological, and even behavioral changes. In this study, functional magnetic resonance imaging (functional magnetic resonance imaging, fMRI) study of SD for the brain perform different control functions and working memory components and the impact of different processes, and the use of resting state (resting state) to connect the next brain function (functional connectivity ) This relatively new research methods to further explore the sleep deprivation on brain function.In this study, after controlled trials for their own design. 14 normal young male volunteers (25.9 ± 2.3 years) participated in SD experiment. Experiment is divided into three parts: first, the application of visual Go / nogo test of SD on brain function of executive control; second, SD for the working memory study (working memory, WM) impact. Which according to Baddeley working memory model to the classic paradigm of n-back test of working memory, respectively, of voice, spatial working memory, object working memory fMRI to explore the application; Third, in the resting state, the first two parts according to the conclusions of studies selected Studies have significant seed region (anterior cingulate cortex and the cingulate gyrus before and after), the application of functional connectivity method of sleep deprivation linked to these specific effects of brain intervals.The key findings and conclusions:SD after the implementation of functional decline. Work closely with behavioral inhibition related brain areas are the anterior cingulate gyrus (anterior cingulated http://www.everbeenmagnet.com/en/products/110-sintered-neodymium-magnets cortex, ACC), parietal cortex (parietal lobe, PL), prefrontal cortex (prefrontal cortex, PFC), wedge leaves and cerebellum. Sleep deprivation and behavioral suppression decreased functional activity of the anterior cingulate progressive decline. With the sleep deprivation time, the prefrontal cortex (BA10) increased activity, increased activity of this function is an important body function compensatory expression. Compensatory body functions operating in the performance of behavioral inhibition in a very obvious.After the decline in working memory capacity SD. And working memory are closely related to brain areas prefrontal cortex, posterior parietal cortex and supplementary motor area (supplementary motor area, SMA), etc. Lead to increased working memory load and memory-related brain activation intensity increased, rather than the more brain regions involved. Different types of sleep deprivation on working memory tasks were different. Working memory for spatial and object and is mainly related to working memory storage and processing activities of the regional function decline. For the voice of working memory, in addition to working memory storage and processing-related decline in brain function, but with attention to the relevant system (BA10, ACC) feature increases the performance of functional compensation. Individual for the sleep deprivation also have some adaptive changes, which mainly reflects the function of the prefrontal cortex on compensation. Compensatory function of the prefrontal cortex increased after sleep deprivation is an important feature.In recent years, researchers found that the brain in the resting state of non-task when there are specific brain regions formed by the initiative of brain activity network, called the default network. Default network including the prefrontal cortex, parietal cortex, cingulate cortex before and after, these brain regions function of network composition is mainly used for the maintenance of wakefulness, and attention of the system play a role in the body are closely related. Sleep deprivation by resting state fMRI study of the brain was found in the default network functional connectivity in sleep deprivation increased, reflecting the coherence of the system default network functional changes, which is the body's attention, suppression of the decline, a clear decline in the relevant state . As for the process of sleep deprivation, hypothalamic function connected with the emergence of pre-and post cingulate opposite change, indicating that the extension of time as sleep deprivation, excessive hypothalamic activity in an activated state.Overall, in the case of sleep deprivation, the body down and pay attention to the level of functional decline in the default network. At this point the body to mobilize the thalamus and other subcortical regions so that in the over-load conditions, while the prefrontal cortex involved in the maintenance of wakefulness, especially in the subcortical structures has not independently maintain a clear state of the case.Resting state fMRI studies in recent years, functional brain imaging studies of the hot spots. In this paper, the resting state of sleep deprivation on brain function is a complement to the traditional task of research and progress, and help us further understand the sleep deprivation on human brain function.Degree Year: 2009